Autor: |
Hui Peng, Zhifa Zhang, Yingjun Wu, Yalan Zhu |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
|
Zdroj: |
Journal of the Egyptian National Cancer Institute, Vol 36, Iss 1, Pp 1-8 (2024) |
Druh dokumentu: |
article |
ISSN: |
2589-0409 |
DOI: |
10.1186/s43046-024-00228-0 |
Popis: |
Abstract Background Lymph node (LN) metastasis is one of the most important indicators to evaluate stage, choose treatment strategy, and predict outcome of colorectal cancer (CRC). The morphological correlation between primary tumors and LN metastases can help predict the incidence of LN metastasis in CRC more accurately and assist with more individualized risk-stratification management decisions. Methods A retrospective study was devised with paired tissue specimens from the invasive front of primary tumors and LN metastases in 426 patients after a radial surgery for CRC. According to the presence (N +) or absence (N-) of regional LN metastasis and the number of LN metastases (pN1a/1b/1c/2a/2b), comparisons were performed regarding tumor budding (TB) and poorly-differentiated clusters (PDC). In addition, their correlation with the incidence of LN metastasis and the extent were explored. Results The TB and PDC in the invasive front of primary tumors presented significant correlations with the incidence of LN metastasis and the number of LN metastases in CRC (P |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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