Characteristics of voluntary reporting of adverse drug events related to antipsychotics in Australia: 14-year analysis
| Autor: | Hanan Khalil, Dimi Hoppe, Nabil Ameen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Drug Safety, Vol 12 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2042-0994 20420986 |
| DOI: | 10.1177/20420986211012854 |
| Popis: | Background: Retrospective analyses of large databases of treated patients can provide useful links to the presence of drug misuse or rare and infrequent adverse effects, such as agranulocytosis, diabetic ketoacidosis or neuroleptic malignant syndrome. The aim of this study is to describe the adverse effects to antipsychotics reported in the Australian Database of Adverse Event Notifications (DAEN). Methods: Data were collected from the DAEN – a spontaneous reporting database. The database, which covered the period from January 2004 to December 2017, was obtained from the Therapeutic Goods Administration (TGA) website ( www.TGA.gov ). The drugs selected for this investigation are the following: aripiprazole, clozapine, olanzapine, paliperidone, risperidone, ziprasidone, quetiapine, haloperidol and pimozide. All data were analysed descriptively. Comparison of reporting and management of adverse events between adults (older than 20 years) and children (5–19 years) was undertaken using chi squared test, where p |
| Databáze: | Directory of Open Access Journals |
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