High-throughput screening for optimizing adoptive T cell therapies

Autor:	Yuchen Zhang, Qinglong Xu, Zhifei Gao, Honghao Zhang, Xiaoling Xie, Meifang Li
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	High-throughput screening Adoptive T cell therapies Genetic screening Non-genetic screening CRISPR screening CAR-T cells Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-30 (2024)
Druh dokumentu:	article
ISSN:	2162-3619 66600049
DOI:	10.1186/s40164-024-00580-w
Popis:	Abstract Adoptive T cell therapy is a pivotal strategy in cancer immunotherapy, demonstrating potent clinical efficacy. However, its limited durability often results in primary resistance. High-throughput screening technologies, which include both genetic and non-genetic approaches, facilitate the optimization of adoptive T cell therapies by enabling the selection of biologically significant targets or substances from extensive libraries. In this review, we examine advancements in high-throughput screening technologies and their applications in adoptive T cell therapies. We highlight the use of genetic screening for T cells, tumor cells, and other promising combination strategies, and elucidate the role of non-genetic screening in identifying small molecules and targeted delivery systems relevant to adoptive T cell therapies, providing guidance for future research and clinical applications.
Databáze:	Directory of Open Access Journals
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