Lower intrathecal morphine doses versus conversion doses in cancer pain

Autor: F. Amato, R. Siciliano, M. Loizzo
Jazyk: English<br />Italian
Rok vydání: 2011
Předmět:
Zdroj: Pathos, Vol 18, Iss 2-3, Pp 11-17 (2011)
Druh dokumentu: article
ISSN: 1593-2354
Popis: Advanced studies in cancer related pain have demonstrated that intrathecal administration of opioids has been much more effective than other drug-administrating routes.The most frequently used drug has been morphine which is the first opioid approved by the US Food and Drug Administration (FDA) for intra-spinal use.Practical conversion rules for different morphine administrating routes were given by Foley et al (1985).Those doses and concentrations are now recommended as a starting doseguideline for the initial phase of treatment.Dosage indicators should be assessed and individualized based on patient response, analgesic requirements and side effects.Therefore, we are herewith presenting findings from a study regardingmorphine doses compared to conversion doses (as per our algorithm) in chronic cancer pain during drug-administration by spinal route.
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