Simulated Moving Bed Chromatography – The Next Step in HPLC
| Autor: | Thomas van Oordt, Edwin Bayliss, Thomas Netscher, Werner Bonrath, Thomas Spielmann |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 60, Iss 3 (2006) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| DOI: | 10.2533/000942906777674967 |
| Popis: | Simulated Moving Bed (SMB) technology, a continuous chromatographic separation process, is of increasing interest in the field of pharmaceuticals, fine chemicals, and biotechnology. The complexity of SMB asks for a deeper understanding of the mathematical design and physical adsorption processes, along with the practical training in chromatography and process engineering. This makes SMB a technology which is also suitable for educational purposes. The principle of SMB separation is described with a short introduction of its mathematical design for a simulation. A method of measuring the adsorption isotherms, which are crucial for a process simulation, is also discussed. As an example, the application of SMB to the separation of two groups of biologically important vitamin E compounds, i.e. tocopherols and tocotrienols from natural-source material is presented. |
| Databáze: | Directory of Open Access Journals |
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