| Autor: |
Hiroyuki Yanagawa, Hitoshi Suzuki, Yusuke Suzuki, Krzysztof Kiryluk, Ali G Gharavi, Kiyoshi Matsuoka, Yuko Makita, Bruce A Julian, Jan Novak, Yasuhiko Tomino |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 9, Iss 5, p e98081 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0098081 |
| Popis: |
There is increasing evidence that galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complexes are important for the pathogenesis of IgA nephropathy (IgAN). In the present study, we assessed a novel noninvasive multi-biomarker approach in the diagnostic test for IgAN.We compared serum levels of IgA, IgG, Gd-IgA1, Gd-IgA1-specific IgG and Gd-IgA1-specific IgA in 135 IgAN patients, 79 patients with non-IgAN chronic kidney disease (CKD) controls and 106 healthy controls. Serum was collected at the time of kidney biopsy from all IgAN and CKD patients.Each serum marker was significantly elevated in IgAN patients compared to CKD (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
