Short QT intervals in African lions

Autor: Frederik S. Scharling, Ditte‐Mari Sandgreen, Julia Stagegaard, Vibeke S. Elbrønd, Stefano Vincenti, Jonas L. Isaksen, Tobias Wang, Rory P. Wilson, Richard Gunner, Nikki Marks, Stephen H. Bell, Martin C. vanRooyen, Nigel C. Bennett, Daniel W. Hart, Angela C. Daly, Mads F. Bertelsen, D. Michael Scantlebury, Kirstine Calloe, Morten B. Thomsen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Experimental Physiology, Vol 109, Iss 12, Pp 2088-2099 (2024)
Druh dokumentu: article
ISSN: 1469-445X
0958-0670
DOI: 10.1113/EP092203
Popis: Abstract The cardiac conduction system in large carnivores, such as the African lion (Panthera leo), represents a significant knowledge gap in both veterinary science and in cardiac electrophysiology. Short QT intervals have been reported from zoo‐kept, anaesthetized lions, and our goal was to record the first ECGs from wild, conscious lions roaming freely, and compare them to zoo‐kept lions under the hypothesis that short QT is unique to zoo‐kept lions. Macroscopic and histological examinations were performed on heart tissue removed from nine healthy zoo lions. ECGs were recorded from the nine anaesthetized zoo‐kept lions, and from 15 anaesthetized and conscious wild lions in Africa. Our histological and topographical description of the lion's heart matched what has previously been published. In conscious lions, the ECG recordings revealed a mean heart rate of 70 ± 4 beats/min, with faster heart rates during the night. PQ and QT intervals were heart rate dependent in the conscious lions. Interestingly, QT intervals recorded in wild lions were markedly longer than QT intervals from zoo lions (398 ± 40 vs. 297 ± 9 ms, respectively; P
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