Differing growth responses to nutritional supplements in neighboring health districts of Burkina Faso are likely due to benefits of small-quantity lipid-based nutrient supplements (LNS).

Autor: Sonja Y Hess, Janet M Peerson, Elodie Becquey, Souheila Abbeddou, Césaire T Ouédraogo, Jérôme W Somé, Elizabeth Yakes Jimenez, Jean-Bosco Ouédraogo, Stephen A Vosti, Noël Rouamba, Kenneth H Brown
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: PLoS ONE, Vol 12, Iss 8, p e0181770 (2017)
Druh dokumentu: article
ISSN: 1932-6203
01860453
DOI: 10.1371/journal.pone.0181770
Popis: Of two community-based trials among young children in neighboring health districts of Burkina Faso, one found that small-quantity lipid-based nutrient supplements (LNS) increased child growth compared with a non-intervention control group, but zinc supplementation did not in the second study.We explored whether the disparate growth outcomes were associated with differences in intervention components, household demographic variables, and/or children's morbidity.Children in the LNS study received 20g LNS daily containing different amounts of zinc (LNS). Children in the zinc supplementation study received different zinc supplementation regimens (Z-Suppl). Children in both studies were visited weekly for morbidity surveillance. Free malaria and diarrhea treatment was provided by the field worker in the LNS study, and by a village-based community-health worker in the zinc study. Anthropometric assessments were repeated every 13-16 weeks. For the present analyses, study intervals of the two studies were matched by child age and month of enrollment. The changes in length-for-age z-score (LAZ) per interval were compared between LNS and Z-Suppl groups using mixed model ANOVA or ANCOVA. Covariates were added to the model in blocks, and adjusted differences between group means were estimated.Mean ages at enrollment of LNS (n = 1716) and Z-Suppl (n = 1720) were 9.4±0.4 and 10.1±2.7 months, respectively. The age-adjusted change in mean LAZ per interval declined less with LNS (-0.07±0.44) versus Z-Suppl (-0.21±0.43; p
Databáze: Directory of Open Access Journals
Externí odkaz: