| Autor: |
Kristine Giltvedt, Luciano S. Voutour, Brianna Tursellino, Alexandra Zella, Susan M. Brasser, Mee Young Hong |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 14, Iss , Pp 200132- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2772-4875 |
| DOI: |
10.1016/j.ijcrp.2022.200132 |
| Popis: |
Objective: It is critical to understand how moderate ethanol exposure interacts with dietary components such as essential fatty acids to influence inflammatory processes underlying CVD pathogenesis. The purpose of this study was to examine the effects of moderate ethanol consumption and dietary n-6:n-3 fatty acid composition on markers associated with CVD in mice. Methods: Twenty-three C57BL/6J mice consumed an 18% ethanol solution or 26.9% maltose dextrin solution (isocaloric control) for 12 weeks. Within each group, the mice were fed either a high n-6 (n-6:n-3 = 50:1) diet or a balanced n-3 (n-6:n-3 = 1:1) diet ad libitum. Following the exposure period, serum samples were analyzed to assess lipid profile, inflammatory markers, antioxidant capacity, DNA damage, and liver function enzyme activity. Results: The control group gained more weight than the ethanol group (P = 0.020). In ethanol-exposed mice, HDL was significantly increased (P = 0.009). C-reactive protein (CRP; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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