Impact of oil type on the development and oral bioavailability of self-nanoemulsifying drug delivery systems containing simvastatin

Autor:	Aya Hamdy, Mahmoud El-Badry, M. Fathy, Ahmed M. El-Sayed
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Essential oil Ethyl oleate SNEDDS Pharmacodynamic study Pharmacokinetic study Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-71980-5
Popis:	Abstract The aim of this work is to develop and evaluate self-nanoemulsifying drug delivery systems (SNEDDS) containing simvastatin to increase its oral bioavailability. Formulation EO 5 (Ethyl oleate 9.3% w/w: Tween 80 49.4% w/w: Propylene glycol 39.3% w/w) and Formulation CL 14 (Clove oil 54.3% w/w: Tween 80 34.4% w/w: Transcutol-P 9.3% w/w) were thoroughly studied. They showed emulsification time less than 1 min, droplet size in the nanometric range, and almost a complete drug release after 2 h. The in-vitro dissolution profile of both formulations was found to be significant in comparison to the pure drug in pH 1.2 and 7.4 buffers (P
Databáze:	Directory of Open Access Journals
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