Secondary hemophagocytic syndrome in an acquired immunodeficiency syndrome and Alpha-thalassemia patient infected with Talaromyces marneffei: A case report and literature review

Autor: Qingqing Wu, Yixiu Yu, Shenhong Feng, Bingqian Fang, Renzhi Zheng, Weidong Sun, Jianzhi Zhao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: IDCases, Vol 36, Iss , Pp e01954- (2024)
Druh dokumentu: article
ISSN: 2214-2509
DOI: 10.1016/j.idcr.2024.e01954
Popis: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease characterized by a hyperinflammatory syndrome and impairment of multiple organ systems. Talaromycosis marneffei (TSM) is an opportunistic infection mostly found in immunosuppressed populations, such as those with acquired immunodeficiency syndrome (AIDS), and is prevalent in southern China. However, HLH secondary to TSM is extremely rare and has only been reported in isolated cases. A 30-year-old patient with recurrent high fever and progressive cytopenia was diagnosed with HLH secondary to disseminated TSM with AIDS and Alpha-thalassemia. The patient remained in sustained remission without recurrence after effective treatment with antifungals and glucocorticoids.
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