Evaluation of methylenetetrahydrofolate reductase (MTHFR) activity and the levels of homocysteine and malondialdehyde (MDA) in the serum of women with preeclampsia

Autor: Sahar Mazloomi, Shohreh Alimohammadi, Iraj Khodadadi, Tayebeh Ghiasvand, Gholamreza Shafiee
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Clinical and Experimental Hypertension, Vol 42, Iss 7, Pp 590-594 (2020)
Druh dokumentu: article
ISSN: 1064-1963
1525-6006
10641963
DOI: 10.1080/10641963.2020.1739700
Popis: Background Methylenetetrahydrofolate reductase (MTHFR) has a key role in converting homocysteine to methionine so its deficiency might cause homocysteine accumulation and arterial destruction. The aim of this study was to evaluate the activity of methylenetetrahydrofolate reductase (MTHFR), homocysteine, and MDA levels in preeclampsia patients. Material and Methods In this case–control study, 30 preeclampsia patients and 30 healthy pregnant women as control group were selected and matched for maternal age, gestational age, and BMI. Preeclampsia was confirmed by examining hypertension and urinary proteinuria. Serum homocysteine and MDA level as well as MTHFR activity were measured manually. Results Homocysteine and MDA levels were significantly different between women with preeclampsia and normal pregnancies (p-value
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