Autor: |
Zbynek Svoboda, Jiri Janota, Milan Slosarek, Zelmira Odlerova, Katarina Kralova, Jiri Kunes, Karel Waisser, Lenka Kubicova |
Jazyk: |
angličtina |
Rok vydání: |
2000 |
Předmět: |
|
Zdroj: |
Molecules, Vol 5, Iss 5, Pp 714-726 (2000) |
Druh dokumentu: |
article |
ISSN: |
1420-3049 |
DOI: |
10.3390/50500714 |
Popis: |
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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