Formulation and evaluation of pH-sensitive rutin nanospheres against colon carcinoma using HCT-116 cell line

Autor:	Marwa H. Asfour, Amira M. Mohsen
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Rutin pH sensitive nanospheres Colon targeting Cytotoxicity Anti-cancer HCT-116 cell line Medicine (General) R5-920 Science (General) Q1-390
Zdroj:	Journal of Advanced Research, Vol 9, Iss C, Pp 17-26 (2018)
Druh dokumentu:	article
ISSN:	2090-1232 2090-1224
DOI:	10.1016/j.jare.2017.10.003
Popis:	The objective of this study was to target rutin, in a more solubilized form, to the colon aiming at treatment of colon carcinoma. pH sensitive nanospheres were prepared by the nanoprecipitation technique employing Eudragit S100. Different drug: polymer ratios as well as different concentrations of the stabilizer Poloxamer-188 were used. The developed rutin nanospheres exhibited entrapment efficiency ranging from 94.19% to 98.1%, with a zeta potential values
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/be846a301f0f4f73ab3165b594b4ba75 Zobrazit plný text záznamu View record in DOAJ