Phenotype of new daily persistent headache: subtypes and comparison to transformed chronic daily headache

Autor: Sanjay Cheema, Anker Stubberud, Khadija Rantell, Parashkev Nachev, Erling Tronvik, Manjit Matharu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Journal of Headache and Pain, Vol 24, Iss 1, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 1129-2377
DOI: 10.1186/s10194-023-01639-5
Popis: Abstract Background It is unknown whether new daily persistent headache (NDPH) is a single disorder or heterogenous group of disorders, and whether it is a unique disorder from chronic migraine and chronic tension-type headache. We describe a large group of patients with primary NDPH, compare its phenotype to transformed chronic daily headache (T-CDH), and use cluster analysis to reveal potential sub-phenotypes in the NDPH group. Methods We performed a case–control study using prospectively collected clinical data in patients with primary NDPH and T-CDH (encompassing chronic migraine and chronic tension-type headache). We used logistic regression with propensity score matching to compare demographics, phenotype, comorbidities, and treatment responses between NDPH and T-CDH. We used K-means cluster analysis with Gower distance to identify sub-clusters in the NDPH group based on a combination of demographics, phenotype, and comorbidities. Results We identified 366 patients with NDPH and 696 with T-CDH who met inclusion criteria. Patients with NDPH were less likely to be female (62.6% vs. 73.3%, p
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