| Autor: |
Matjaž Ravnikar, Borut Štrukelj, Biljana Otašević, Mateja Sirše |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Nutraceuticals, Vol 4, Iss 2, Pp 273-282 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1661-3821 |
| DOI: |
10.3390/nutraceuticals4020017 |
| Popis: |
The present study screened various fungal species for inhibitors of alpha-glucosidase, alpha-amylase, and DPP-4, enzymes that are crucial in carbohydrate metabolism. Ethanolic extracts exhibited superior inhibitory activity compared to water extracts, suggesting their potential as sources of anti-diabetic agents. Further fractionation revealed fomentariol from Fomes fomentarius as a potent inhibitor of alpha-glucosidase and DPP-4, with higher activity against alpha-glucosidase than acarbose. Fomentariol presents a novel avenue for diabetes management, demonstrating the simultaneous inhibition of key enzymes in glucose metabolism. However, comprehensive clinical studies are needed to evaluate its safety and efficacy in humans. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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