A Novel ROS1 Oncogenic Fusion Detected on Next Generation Sequencing

Autor: Anurag Mehta, Himanshi Diwan, Shrinidhi Nathany, Ullas Batra, Manoj Gupta, Manoj Kumar Panigrahi, Dushyant Kumar, Sakshi Mattoo, Aayushi Singh
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical Pathology, Vol 17 (2024)
Druh dokumentu: article
ISSN: 2632-010X
2632010X
DOI: 10.1177/2632010X241269373
Popis: Advanced Non-Small Cell Lung Carcinoma (NSCLC) patients with ROS1 gene rearrangement have shown significant therapeutic responses to tyrosine kinase inhibitors approved by the US Food and Drug Administration, with approximately 40 fusion partners documented in the existing literature. Our report highlights a novel fusion partner of ROS1 that has demonstrated a conclusive response to the current standard of treatment.
Databáze: Directory of Open Access Journals
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