| Autor: |
Renata Moll-Bernardes, Sérgio C. Fortier, Andréa S. Sousa, Renato D. Lopes, Narendra Vera, Luciana Conde, André Feldman, Guilherme Arruda, Mauro Cabral-Castro, Denílson C. Albuquerque, Thiago C. Paula, Thyago Furquim, Vitor A. Loures, Karla Giusti, Nathália Oliveira, Ariane Macedo, Pedro Barros e Silva, Fábio De Luca, Marisol Kotsugai, Rafael Domiciano, Flávia A. Silva, Mayara F. Santos, Olga F. Souza, Fernando A. Bozza, Ronir R. Luiz, Emiliano Medei |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Clinical Medicine, Vol 11, Iss 13, p 3713 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2077-0383 |
| DOI: |
10.3390/jcm11133713 |
| Popis: |
Cardiovascular comorbidities and immune-response dysregulation are associated with COVID-19 severity. We aimed to explore the key immune cell profile and understand its association with disease progression in 156 patients with hypertension that were hospitalized due to COVID-19. The primary outcome was progression to severe disease. The probability of progression to severe disease was estimated using a logistic regression model that included clinical variables and immune cell subsets associated with the primary outcome. Obesity; diabetes; oxygen saturation; lung involvement on computed tomography (CT) examination; the C-reactive protein concentration; total lymphocyte count; proportions of CD4+ and CD8+ T cells; CD4/CD8 ratio; CD8+ HLA-DR MFI; and CD8+ NKG2A MFI on admission were all associated with progression to severe COVID-19. This study demonstrated that increased CD8+ NKG2A MFI at hospital admission, in combination with some clinical variables, is associated with a high risk of COVID-19 progression in hypertensive patients. These findings reinforce the hypothesis of the functional exhaustion of T cells with the increased expression of NKG2A in patients with severe COVID-19, elucidating how severe acute respiratory syndrome coronavirus 2 infection may break down the innate antiviral immune response at an early stage of the disease, with future potential therapeutic implications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
