| Autor: |
Takanobu Yoshii, Naoya Oishi, Yasutaka Sotozono, Anri Watanabe, Yuki Sakai, Shunji Yamada, Ken-Ichi Matsuda, Masamitsu Kido, Kazuya Ikoma, Masaki Tanaka, Jin Narumoto |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-024-53103-2 |
| Popis: |
Abstract Major depressive disorder is a common psychiatric condition often resistant to medication. The Wistar-Kyoto (WKY) rat has been suggested as an animal model of depression; however, it is still challenging to translate results from animal models into humans. Solitary housing is a mild stress paradigm that can simulate the environment of depressive patients with limited social activity due to symptoms. We used voxel-based morphometry to associate the solitary-housed WKY (sWKY) rat model with data from previous human studies and validated our results with behavioural studies. As a result, atrophy in sWKY rats was detected in the ventral hippocampus, caudate putamen, lateral septum, cerebellar vermis, and cerebellar nuclei (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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