| Autor: |
Jia‐Yi Huang, Yap‐Hang Chan, Yi‐Kei Tse, Si‐Yeung Yu, Hang‐Long Li, Cong Chen, Chun‐Ting Zhao, Ming‐Ya Liu, Mei‐Zhen Wu, Qing‐Wen Ren, Ka‐Lam Leung, Denise Hung, Xin‐Li Li, Hung‐Fat Tse, Gregory Y. H. Lip, Kai‐Hang Yiu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.123.032378 |
| Popis: |
Background Whether statin use can reduce the risk of heart failure (HF) remains controversial. The present study evaluates the association between statin use and HF in patients with atrial fibrillation. Methods and Results Patients with newly diagnosed atrial fibrillation from 2010 to 2018 were included. An inverse probability of treatment weighting was used to balance baseline covariates between statin users (n=23 239) and statin nonusers (n=29 251). The primary outcome was incident HF. Cox proportional hazard models with competing risk regression were used to evaluate the risk of HF between statin users and nonusers. The median age of the cohort was 74.7 years, and 47.3% were women. Over a median follow‐up of 5.1 years, incident HF occurred in 3673 (15.8%) statin users and 5595 (19.1%) statin nonusers. Statin use was associated with a 19% lower risk of HF (adjusted subdistribution hazard ratio, 0.81 [95% CI, 0.78–0.85]). Restricted to the statin users, duration of statin use was measured during follow‐up; compared with short‐term use (3 months to |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text