Cholesterol and ApoE in Alzheimer’s disease

Autor: Potier Marie-Claude, Hanbouch Linda, Marquer Catherine
Jazyk: English<br />French
Rok vydání: 2018
Předmět:
Zdroj: Oilseeds and fats, crops and lipids, Vol 25, Iss 4, p D407 (2018)
Druh dokumentu: article
ISSN: 2272-6977
2257-6614
DOI: 10.1051/ocl/2018038
Popis: Genetic, neuropathological and biochemical studies suggest strong links between cholesterol, the apolipoprotein E (APOE) and Alzheimer’s disease (AD), both in humans and in animal models of the disease. From the literature and our work, we can predict that transient increase of the levels of cholesterol at the membrane of neurons would profoundly affect the processing of the transmembrane Amyloid Precursor Protein (APP) by triggering its clathrin dependent endocytosis and the resulting production of amyloid-β (Aβ) peptides. Here, we will review these data together with structural and molecular dynamic studies that characterized the role of cholesterol on APP conformation and positioning at the membrane. Specifically decreasing brain cholesterol or replacing it with plant sterols crossing the blood brain barrier appear like promising strategies to either delay or counteract the development of sporadic AD.
Databáze: Directory of Open Access Journals
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