Investigating the cyto-compatibility of ZrNbVTiAl high entropy alloy

Autor: P. Chakraborty, R.K. Chittela, S. Samal, A. Sarkar, A.V.S.S.N. Rao, S. Neogy, R. Tewari
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Alloys and Metallurgical Systems, Vol 6, Iss , Pp 100076- (2024)
Druh dokumentu: article
ISSN: 2949-9178
DOI: 10.1016/j.jalmes.2024.100076
Popis: An investigation was carried out to assess the suitability of equiatomic ZrNbVTiAl high-entropy alloy (HEA) for biomedical applications. This included microstructural analysis, mechanical property evaluation and in–vivo testing in biological media to examine its cyto-compatibility. The alloy developed a dendritic structure on solidification through arc melting, with BCC –B2 type dendrites separated by inter-dendritic regions rich in Al and Zr. The evolved microstructure and composition matched well with those predicted by the phase field modelling. The HEA also showed a high yield strength (1045 MPa) and moderate elastic modulus (120 GPa) comparable to the commonly used biomedical alloy, Ti-6Al-4 V. Cell culture studies with U2OS Cells showed substantial attachment and growth of healthy osteoblasts to the HEA as well as negligible bio-corrosion after 45 days of exposure. Most importantly, the alloy showed a significantly high tendency of cell attachment than pure Ti and lower magnetic susceptibility (2.55 ×10−6 cm3/g) than Ti-6Al-4 V alloy indicating its suitability for biomedical applications.
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