| Autor: |
Michael Oertel, MD, Dominik Hering, MSc, Nina Nacke, MSc, Christopher Kittel, MSc, Kai Kröger, MD, Jan Kriz, MD, Michael Fuchs, MD, Christian Baues, MD, Dirk Vordermark, MD, Rita Engenhart-Cabillic, MD, Klaus Herfarth, MD, Peter Lukas, MD, Heinz Schmidberger, MD, Simone Marnitz, MD, Peter Borchmann, MD, Andreas Engert, MD, Uwe Haverkamp, Hans Theodor Eich, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Advances in Radiation Oncology, Vol 8, Iss 3, Pp 101169- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2452-1094 |
| DOI: |
10.1016/j.adro.2022.101169 |
| Popis: |
Purpose: Radiation therapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. This analysis reports on RT quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods and Materials: All RT plans of involved-node radiation therapy (INRT) in HD 17 were requested for analysis, along with 100 and 50 involved-field radiation therapy (IFRT) plans in HD 16 and 17, respectively. A structured assessment regarding field design and protocol adherence was performed by the reference radiation oncology panel of the GHSG. Results: Overall, 100 (HD 16) and 176 (HD 17) patients were eligible for analysis. In HD 16, 84% of RT series were evaluated as correct, with significant improvement compared with the predecessor studies (P < .001). In HD 17, 76.1% of INRT cases revealed a correct RT design compared with 69.0% of IFRT-cases, which was superior to previous studies (P < .001). Comparing INRT and IFRT, we found no significant differences in the percentage of any deviation (P = .418) or major deviations (P = .466). Regarding dosimetry, INRT was accompanied by an improvement in thyroid doses. Comparing different RT techniques, we found that intensity-modulated RT showed a reduction of high doses in the lung at the expense of an increased low-dose exposure in HD 17. Conclusions: The latest study generation of the GHSG demonstrates an improved quality in RT. A modern INRT design could be established without deterioration in quality. On a conceptual level, an individual consideration of the appropriate RT technique has to be performed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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