PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis.

Autor: Samantha Y Quintanilla, Neda Habibi Arejan, Parthvi B Patel, Cara C Boutte
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: PLoS ONE, Vol 18, Iss 1, p e0280336 (2023)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0280336
Popis: Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci.
Databáze: Directory of Open Access Journals
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