| Autor: |
Nouf Hijazi, MD, Amir Rahemtulla, MD, Chen Zhou, MD, PhD, Thomas Thomson, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Human Pathology: Case Reports, Vol 1, Iss 4, Pp 58-61 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
2214-3300 |
| DOI: |
10.1016/j.ehpc.2014.09.008 |
| Popis: |
In the salivary gland, a key differential feature of Mammary analog secretory carcinoma (MASC) from acinic cell carcinoma (ACC) is the lack of cytoplasmic granules. We report a case of a parotid mass incorrectly diagnosed on fine needle aspirate as acinic cell carcinoma due to many cells with basophilic granules suggesting serous acinar differention. Tumor resection revealed a tumor consistent with low grade adenocarcinoma that had eosinophilic, microvacuolar cytoplasm with distinct basophilic granules staining with PASD and mucicarmine. The diagnosis of MASC was confirmed with stains for GCDF-15, mammoglobin, and S100 and FISH consistent with a t(12;15) translocation. Relying on the absence of cytoplasmic granules as a feature to distinguish ACC from MASC is a diagnostic pitfall. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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