A comparison of ondansetron and lidocaine in reducing injection pain of propofol: a randomized controlled study

Autor: Wirat Wasinwong, Sarocha Termthong, Prae Plansangkate, Jutarat Tanasansuttiporn, Riam Kosem, Surewan Chaofan
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Anesthesiology, Vol 22, Iss 1, Pp 1-7 (2022)
Druh dokumentu: article
ISSN: 1471-2253
DOI: 10.1186/s12871-022-01650-4
Popis: Abstract Background Direct stimulation of the afferent nerve endings in the venous endothelium is one explanation of propofol injection pain. Previous studies found that ondansetron can also block sodium channels. This effect is similar to that of lidocaine. Objective The primary outcome was the efficacy of ondansetron compared to lidocaine and placebo for the reduction of propofol injection pain. Method This trial was conducted in 240 patients, American Society of Anesthesiologists classification I-III and aged between 18–65 years old, undergoing elective surgery, and having a 20-gauge intravenous catheter at the hand dorsum. Each group of 80 patients received 8 mg. of ondansetron in the O Group, 40 mg. of lidocaine in the L Group and normal saline in the C Group. The study medications were blindly administered to the patients through a 20-gauge intravenous catheter placed on the hand dorsum, and then 1 min later, the small dose of propofol (50 mg.) was infused via the syringe pump at a rate of 600 ml/hr. for 30 s. Following that, the syringe pump of propofol was temporarily stopped, and the patients were asked to rate their pain at the injection site. Result The incidence of pain was lowest in the L group (66.2%) compared with the O (82.5%) and the C groups (85.0%) (P
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