Study of structural-mechanical properties for choosing the basis of pharmaceutical composition in ointment form
| Autor: | A. V. Lutska, A. O. Drozdova |
|---|---|
| Jazyk: | ukrajinština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Фармацевтичний журнал, Vol 3, Pp 55-60 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0367-3057 2617-9628 |
| DOI: | 10.32352/0367-3057.3.22.06 |
| Popis: | Rational treatment of wounds is a pressing problem of our time, especially during hostilities. Practice has shown that currently there is no universal method of local wound healing. Therefore, a differentiated approach to the development of drugs for the local treatment of the wound process is needed. Among the dosage forms for topical use, soft drugs are a convenient dosage form for topical use. Thanks to the excipients which are a part of soft medicines, it is possible to regulate release of active pharmaceutical ingredients that, in turn, provides medical action of drug. The technology of drug preparation, which includes the substantiation of the temperature regime of drug production, the study of their physico-chemical and structural-mechanical properties affects the therapeutic efficacy of the drug. The aim of the work was to study the structural and mechanical properties of model samples for choosing the basis of the pharmaceutical composition in the form of an ointment. The object of the study were model samples of bases made on the basis of oil/water emulsion and water/oil. Measurements of rheological parameters of ointment bases and their homogeneity were performed according to the methods of the State Pharmacopoeia of Ukraine (2.2.10 and SPU 1 in Annex I). Studies of thermal stability and colloidal stability were performed according to DSTU 4765: 2007. Cosmetic creams. General technical conditions. [Effective from 2009-01-01]. Rheological studies of model samples of ointment bases immediately after their manufacture and their physicochemical properties (homogeneity, thermal stability and colloidal stability) both after fabrication and during 6 months of storage at room temperature. It is proved that all samples have elastic-plastic-viscous properties, thixotropy and ability to lubricate well, homogeneity and thermal and colloidal stability. The study of the structural and mechanical properties of model bases has shown that these samples of bases can be used as carriers of drugs in the development of soft drugs. The prospect of this study is to study the osmotic properties of model samples in order to choose the basis that the medical and biological requirements will meet a certain phase of the wound process. |
| Databáze: | Directory of Open Access Journals |
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