Intelligence Quotient and Its Affected Epidemiological Factors in Children with Phenylketonuria in Hamadan Province
| Autor: | Effat Sadat Mirmoeini, Razieh Sadat Mirmoeini, Salman Khazaei, Simin Karimi, Reza Zamani, Mohammad Hasan Sa'ati |
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| Jazyk: | perština |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | پژوهان, Vol 22, Iss 2, Pp 164-172 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1029-7863 2423-6276 |
| Popis: | Background and Objectives: Phenylketonuria (PKU) is a rare hereditary metabolic disease caused by the phenylalanine hydroxylase enzyme (PAH) deficit. Delays in diagnosis and treatment have serious effects on the nervous system and reduce the IQ of these children. Materials and Methods: The current cross-sectional study was conducted on 55 children aged 5 to 18 years with a definite diagnosis of PKU who were taken care of in the Genetic Diseases Control Center, Hamadan Be'sat Hospital. The information of the patients was obtained from the file and interviews with the parents and then recorded in the checklist. For individual measurement of cognitive abilities and IQ, the Stanford Binet Questionnaire was used, and statistical analyses were performed in Stata 16 software. Results: The average age of the children was 11.08 years,52.73% of the samples were children of consanguineous marriage parents, and 29.09% had a history of PKU in the family. The average age of diagnosis was 15.09 months. The disease had been diagnosed in 47% of cases by screening. The IQ of 3.5% of the children was normal, 42% was low average, 43.5% had borderline much lower than average, and 11% suffered from mental retardation. The average age of diagnosis was 5, 15, 13, and 27.5 months, respectively. A significant relationship was found between IQ and the child's age and birth order (P |
| Databáze: | Directory of Open Access Journals |
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