DIFFUSION TENSOR TRACTOGRAPHY IN THE DIAGNOSIS OF CHANGES IN THE CENTRAL DEPARTMENTS OF THE VISUAL ANALYZER IN PRIMARY GLAUCOMA
| Autor: | V. P. Erichev, L. A. Panyushkina, I. A. Novikov, V. S. Reshchikova |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Oftalʹmologiâ, Vol 14, Iss 4, Pp 328-334 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1816-5095 2500-0845 |
| DOI: | 10.18008/1816-5095-2017-4-328-334 |
| Popis: | Purpose. To investigate the potential of diffusion tensor MRT (DT-MRT) in diagnosing the changes of central departments of the visual analyzer in primary open angle glaucoma.Patients and Methods. 16 patients underwent DT-MRT: 12 patients had a prior diagnosis of different stages of glaucoma and 4 acted as controls. Brain examination included both standard (T1, T2, MPR) and special modes (diffusion-weighted imaging with DT tractographic mapping, grey matter morphometry). The main parameter obtained during this exam is fractional anisotropy, which represents brain structures directional organization and integrity. Results. Two main parameters — fractional anisotropy (FA) and fractional anisotropy variability (ΔFA) — were obtained for left and right lateral geniculate body and optic radiation in 3 cross-sections (15–17). We considered FA decrease and ΔFA increase to be the sign of visual pathways integrity loss due to axonal transport defects. Glaucoma patients showed a statistically significant FA decrease in the lower section (FA 14) compared to the control patients (median values 0,74 and 0,77 correspondingly, р |
| Databáze: | Directory of Open Access Journals |
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