Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye

Autor: Pavlos Msaouel, Cheryl L. Walker, Giannicola Genovese, Nizar M. Tannir
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 7, Iss 5 (2020)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2020.1777060
Popis: Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.
Databáze: Directory of Open Access Journals
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