| Autor: |
Y. G. Moysyuk, A. I. Sushkov, N. V. Pulkova, V. Y. Abramov, A. G. Kupriyanova, B. N. Morozov, A. K. Porunova, N. P. Obraztsova, I. Y. Adamova, S. V. Gautier |
| Jazyk: |
ruština |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Vestnik Transplantologii i Iskusstvennyh Organov, Vol 13, Iss 4, Pp 6-18 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1995-1191 |
| DOI: |
10.15825/1995-1191-2011-4-6-18 |
| Popis: |
We report the first Russian experience of successful ABO-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. IA procedures were performed on reusable columns ABO-Adsopak® (POCARD Ltd. Moscow, Russia). IA treatments following the administration of rituximab efficiently lowered the immunoglobulin M (IgM) and G (IgG) anti-A/B antibodies titers in all patients. The transplantation could be performed in all cases and the kidneys showed primary function. Unfortunately, the biopsy-proven clinical antibody-mediated rejection (AMR) occurred in one case. Episo- de of AMR was successfully reversed. On 6, 4 and 2 months follow-up, serum creatinine levels were 117, 127 and 87 μmol/l, respectively. We consider ABO-incompatible transplantation as a safe and promising procedure in particu- lar cases for those patients having related but ABO-incompatible donors. Given the shortage of donor organs ABO- incompatible living donor kidney transplantation may become a treatment of choice for many patients. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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