Early recurrence factors in patients with stage III non‐small cell lung cancer treated with concurrent chemoradiotherapy

Autor: Yutaka Takahara, Takuya Tanaka, Yoko Ishige, Ikuyo Shionoya, Kouichi Yamamura, Takashi Sakuma, Kazuaki Nishiki, Keisuke Nakase, Masafumi Nojiri, Ryo Kato, Shohei Shinomiya, Taku Oikawa, Shiro Mizuno
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Thoracic Cancer, Vol 13, Iss 24, Pp 3451-3458 (2022)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.14704
Popis: Abstract Background The clinical characteristics and risk factors for cancer recurrence have not been well evaluated regarding early recurrence in patients with unresectable locally advanced non‐small cell lung cancer (LA‐NSCLC) who receive concurrent chemoradiotherapy (CRT). The aim of this study was to determine the clinical characteristics and risk factors of patients with stage III unresectable LA‐NSCLC treated with CRT who developed early recurrence. Methods We retrospectively reviewed the clinical records of 46 patients diagnosed with stage III unresectable LA‐NSCLC treated with CRT at our center between July 2012 and July 2021. A tumor proportion score (TPS) 50% was defined as “high expression.” Results A total of 17 (37.0%) patients had a confirmed recurrence within 1 year of treatment. More patients had a lower body mass index in the early recurrence group than in the later recurrence group (p = 0.038). A higher number of patients in the late recurrence group underwent surgery after CRT (p = 0.036). Patients with a higher TPS were more likely to experience late recurrence than early recurrence (p = 0.001), whereas more patients with stage N3 disease were in the early recurrence group (p = 0.011). Multivariate analysis identified lower TPS expression as an independent risk factor for early recurrence after CRT. Overall survival was prolonged in the late recurrence group (p
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