| Autor: |
Zoe L. Hunter, Hannah C. Leeson, Mohammed R. Shaker, Ernst J. Wolvetang, Lata Vadlamudi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Stem Cell Research, Vol 56, Iss , Pp 102564- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1873-5061 |
| DOI: |
10.1016/j.scr.2021.102564 |
| Popis: |
Epilepsy is a common neurological disorder characterized by seizures. Unfortunately, 30–40% of all epilepsy patients are resistant to at least two or more anti-seizure medications. Attempts to treat these patients and prevent further seizures necessitates multiple drug trials for the patient. Here we describe the generation and validation of induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) from 3 drug responsive and 3 drug resistant patients, using a non-integrative Sendai virus vector. These lines can be used to generate 2D and 3D patient-specific human cellular models that will enable personalised drug screening and pharmacogenomic studies. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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