Bisoprolol and magnesium medications in arterial hypertension treatment
| Autor: | A. M. Shilov, M. V. Mel’nik |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | Кардиоваскулярная терапия и профилактика, Vol 4, Iss 1, Pp 36-41 (2005) |
| Druh dokumentu: | article |
| ISSN: | 1728-8800 2619-0125 |
| Popis: | Aim. To investigate therapeutic efficacy of selective beta-1-adrenoblockers combined with magnesium (Mg) medications, in the treatment of arterial hypertension (AH), as well as their role in blood rheology normalization: effects on platelet aggregation activity (APl), red blood cell electrophoretic mobility (RBC EPM), lipid profile, serum and RBC Mg levels. Material and methods. One hundred patients were examined: 20 normotensives (mean age 53.1±5.8 years), and 80 hypertensives with Stage I-II AH (mean age 51.41±6.3 years). Mg deficit – RBC Mg concentration 1.6 mmol/l. Bisoprolol monotherapy (7.5±0.15 mg/d) lasted for 6 months. In subgroup A, bisoprolol was combined with Mg medication. Results. By the end of the treatment, there was a decrease of systolic blood pressure (SBP) by 15%, and diastolic blood pressure (DBP) by 21.3% in subgroup A. In subgroup B, SBP declined by 13.3%, DBP – by 16.3%. RBC Mg concentration correlated with SBP and DBP levels. After 6 months of treatment, APl declined by 31.8% and 19% in subgroups A and B, respectively (р |
| Databáze: | Directory of Open Access Journals |
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