Calcineurin inhibitors and arterial hypertension in recipients of solid organs
| Autor: | E D Kosmacheva, S M Martirosyan, M Kh Lepshokova, A E Babich |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Системные гипертензии, Vol 14, Iss 3, Pp 84-86 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2075-082X 2542-2189 |
| Popis: | Arterial hypertension is an established risk factor for cardiovascular complications. Since the introduction of calcineurin inhibitors (CNI), аrterial hypertension is observed in 50-80% of transplanted patients. Arterial hypertension and transplantation are closely linked, and its association may promote impaired graft and overall survival. We summarize the main mechanisms involved in the genesis of CNI-induced hypertension as follows: impaired renal function with the sodium retaining, endothelial dysfunction, renin-angiotensin-aldosterone system and sympathetic activation, production of vasoconstrictor substances, activation the renal Na+/Cl--cotransporter. Attention is focused on the dose-dependent increase in arterial pressure and the need for further study of the intensity of the pro-hypertensive effect of various calcineurin inhibitors. |
| Databáze: | Directory of Open Access Journals |
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