The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma
| Autor: | Keyhanmanesh Rana, Pejman Laleh, Omrani Hasan, Mirzamohammadi Zahra, Shahbazfar Amir A |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | BioImpacts, Vol 4, Iss 2, Pp 75-81 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2228-5652 2228-5660 |
| DOI: | 10.5681/bi.2014.006 |
| Popis: | Introduction: In previous studies, the relaxant and antihistaminic effects of thymoquinone, the main constituents of Nigella sativa, have been demonstrated on guinea pig tracheal chains. In the present study, the prophylactic effect of (IP) single dose of thymoquinone on tracheal responsiveness and lung inflammation of guinea pig model of asthma was examined. Methods: Thirty guinea pigs were randomly divided to 3 groups; control (C), sensitized (S) and pretreated group with (TQ); 3 mg/kg, IP (S+TQ). Tracheal responsiveness to methacholine and ovalbumin (OA), total and differential cell count in bronchoalveolar lavage, lung pathological changes and blood Interleukin 4(IL-4) and Interferon gamma (IFNγ) level in three groups were measured.Results: Increased tracheal responsiveness to methacholine and OA, lung lavage fluid white blood cell (WBC) and eosinophil count, IL-4 and IFN-γ levels and pathological changes were seen in sensitized group in comparison to control group (p |
| Databáze: | Directory of Open Access Journals |
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