Analysis of KRAS and NRAS mutations in Greek patients with metastatic Colorectal Cancer (mCRC) on the registry of the Gastro-intestinal Cancer Study Group (GIC-SG)

Autor:	Gouvas Nikolaos, Kalambaliki Telenia, Voutsina Alexandra, Saridaki Zenia, Tzardi Maria, Kalykaki Aristea, Sfakianaki Maria, Athanasiadis Athanasios, Xynos Evaghelos, Boukovinas Ioannis, Souglakos John
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	kras-nras mutation colorectal cancer metastatic disease Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Forum of Clinical Oncology, Vol 9, Iss 1, Pp 31-36 (2019)
Druh dokumentu:	article
ISSN:	1792-362X
DOI:	10.2478/fco-2018-0005
Popis:	Several studies show that mutational profiles could influence treatment decisions in patients with metastatic CRC (mCRC). KRAS mutational status was the first step in biomarkers development in the era of molecular targeted therapies. Recently, NRAS mutational status was identified as an independent prognostic factor for the response to treatment with anti-EGFR moAbs. The aim of this observational study was to assess the feasibility of the KRAS/NRAS mutational analysis in patients with metastatic colorectal cancer in Greece and to identify any correlations with known clinical characteristics and histopathologic features.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bd9b256a7b0e4313a8fa70133728181b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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