| Autor: |
Gabriella Sgorlon, Tárcio P Roca, Ana Maisa Passos-Silva, Jackson A S Queiroz, Karolaine S Teixeira, Adrhyan Araújo, Flávia S Batista, Valquiria R Souza, Franciane M Oliveira, Luis G Morello, Fabricio K Marchini, Juan M V Salcedo, Rita de Cassia P Rampazzo, Felipe G Naveca, Deusilene Vieira |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 18, Iss 8, p e0285742 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0285742 |
| Popis: |
Genomic surveillance represents a strategy to understanding the evolutionary mechanisms, transmission, and infectivity of different SARS-CoV-2 variants. We evaluated 603 individuals positive for SARS-CoV-2 from 34 municipalities of Rondônia between December 2021 to December 2022. Nasopharyngeal samples were collected, RNA was extracted and screened using RT-qPCR for VOCs. RNA of the samples were sequenced and further analyzed for phylogeny, mutations, and lineages, totaling 96.19% of samples positive for Omicron VOC in this cohort. We observed that most individuals had at least two doses, however 18.97% were not vaccinated with any dose. 554 sequences were amenable to analysis for alignment and phylogenetic characterization; this group corresponded to the 27 subvariants of the Omicron VOC; a total of 100 mutations were identified, 48% of which were found in the S gene. In conclusion, the data demonstrated the rapid spread and persistence of Omicron VOC in Rondônia during the 12-month study period. Although high frequency of mutations was found in the analyzed samples, there were no individuals with a severe clinical profile, demonstrating that vaccination had a positive effect in those cases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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