Recent Advances on the Structure and Function of RNA Acetyltransferase Kre33/NAT10

Autor:	Sophie Sleiman, Francois Dragon
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	ribosome biogenesis Kre33 NAT10 post-transcriptional modifications SSU processome nuclear pore complex nuclear localization signal nucleolar localization signal Hutchinson–Gilford progeria syndrome Cytology QH573-671
Zdroj:	Cells, Vol 8, Iss 9, p 1035 (2019)
Druh dokumentu:	article
ISSN:	2073-4409 64756203
DOI:	10.3390/cells8091035
Popis:	Ribosome biogenesis is one of the most energy demanding processes in the cell. In eukaryotes, the main steps of this process occur in the nucleolus and include pre-ribosomal RNA (pre-rRNA) processing, post-transcriptional modifications, and assembly of many non-ribosomal factors and ribosomal proteins in order to form mature and functional ribosomes. In yeast and humans, the nucleolar RNA acetyltransferase Kre33/NAT10 participates in different maturation events, such as acetylation and processing of 18S rRNA, and assembly of the 40S ribosomal subunit. Here, we review the structural and functional features of Kre33/NAT10 RNA acetyltransferase, and we underscore the importance of this enzyme in ribosome biogenesis, as well as in acetylation of non-ribosomal targets. We also report on the role of human NAT10 in Hutchinson−Gilford progeria syndrome.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bd7c6475620341b5a5428aea2f2ec713 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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