Association of Internet gaming disorder with catechol‐O‐methyltransferase: Role of impulsivity and fun‐seeking

Autor: Ju‐Yu Yen, Pai‐Cheng Lin, Huang‐Chi Lin, Pei‐Yun Lin, Wei‐Po Chou, Chih‐Hung Ko
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Kaohsiung Journal of Medical Sciences, Vol 38, Iss 1, Pp 70-76 (2022)
Druh dokumentu: article
ISSN: 2410-8650
1607-551X
DOI: 10.1002/kjm2.12454
Popis: Abstract Dopamine functioning is an essential mechanism underlying addictive behaviors. This paper evaluates the association of Internet gaming disorder (IGD) with the catechol‐O‐methyltransferase (COMT) val158met polymorphism and examines the roles of impulsivity and reinforcement sensitivity in this association. Using diagnostic interviews, this study recruited 69 participants with IGD and 138 participants without. All participants underwent diagnostic interviews for IGD and an evaluation for the COMT val158met polymorphism, impulsivity, and reinforcement sensitivity. Among participants with the Val/Val genotype, the odds ratio (95% confidence interval) for IGD was 2.09 (1.15–3.80). The IGD–Val/Val genotype association was mediated by impulsivity and fun‐seeking. The Val/Val genotype is indicative of low frontal functioning and is a predictive factor of IGD, with this effect being confounded by impulsivity and fun‐seeking. Interventions targeting impulsivity and fun‐seeking might attenuate the risk of IGD, particularly among individuals with the Val/Val genotype. Additional studies are necessary to elucidate the possible role of dopamine functioning.
Databáze: Directory of Open Access Journals
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