Neprilysin Is Poorly Expressed in the Prefrontal Cortex of Aged Dogs with Cognitive Dysfunction Syndrome
| Autor: | Jesús Canudas, Daniel Insua, Leticia Sarasa, Ángela González-Martínez, María Luisa Suárez, Germán Santamarina, Pedro Pesini, Manuel Sarasa |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | International Journal of Alzheimer's Disease, Vol 2014 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2090-8024 2090-0252 |
| DOI: | 10.1155/2014/483281 |
| Popis: | Neprilysin (NEP) is the principal amyloid β (Aβ) degrading peptidase; this activity may protect against Alzheimer’s disease (AD), the most important age-related neurodegenerative process. The aim of this work was to analyze NEP mRNA expression in the frontal cortex of dogs with and without canine cognitive dysfunction syndrome (CDS), which is considered a natural model for AD. Expression of canine cerebral NEP mRNA was assessed by RT-PCR followed by qPCR in young, aged-cognitively unimpaired (CU), and aged-cognitively impaired (CI) dogs. On average, aged-CI dogs showed 80% (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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