Multi-Gene Panel Testing in Gastroenterology: Are We Ready for the Results?

Autor:	Flávio Pereira, Manuel R. Teixeira, Mário Dinis Ribeiro, Catarina Brandão
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	multi-gene panel testing gastrointestinal cancer risk hereditary cancer genetic counselling Diseases of the digestive system. Gastroenterology RC799-869
Zdroj:	GE: Portuguese Journal of Gastroenterology, Pp 1-7 (2021)
Druh dokumentu:	article
ISSN:	2341-4545 2387-1954
DOI:	10.1159/000513966
Popis:	Genetic testing aims to identify patients at risk for inherited cancer susceptibility. In the last decade, there was a significant increase in the request of broader panels of genes as multi-gene panel testing became widely available. However, physicians may be faced with genetic findings for which there is lack of management evidence, despite some progress in understanding their clinical relevance. In this short review, we discuss the advantages and the drawbacks related to multi-gene panel testing in the setting of a Gastrointestinal Familial Cancer Risk clinic. We also summarize the available recommendations on management of pathogenic variant carriers.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bd6f13bfa3b9479f9879d2639757894c Zobrazit plný text záznamu View record in DOAJ