RV adaptation to increased afterload in congenital heart disease and pulmonary hypertension.

Autor: Mieke M P Driessen, Tim Leiner, Gertjan Tj Sieswerda, Arie P J van Dijk, Marco C Post, Mark K Friedberg, Luc Mertens, Pieter A Doevendans, Repke J Snijder, Erik H Hulzebos, Folkert J Meijboom
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: PLoS ONE, Vol 13, Iss 10, p e0205196 (2018)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0205196
Popis: BACKGROUND:The various conditions causing a chronic increase of RV pressure greatly differ in the occurrence of RV failure, and in clinical outcome. To get a better understanding of the differences in outcome, RV remodeling, longitudinal function, and transverse function are compared between patients with pulmonary stenosis (PS), those with a systemic RV and those with pulmonary hypertension (PH). MATERIALS AND METHODS:This cross-sectional study prospectively enrolled subjects for cardiac magnetic resonance imaging (CMR), functional echocardiography and cardiopulmonary exercise testing. The study included: controls (n = 37), patients with PS (n = 15), systemic RV (n = 19) and PH (n = 20). Statistical analysis was performed using Analysis of Variance (ANOVA) with posthoc Bonferroni. RESULTS:PS patients had smaller RV volumes with higher RV ejection fraction (61.1±9.6%; p
Databáze: Directory of Open Access Journals
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