Epigenetics and Periodontitis: A Contemporary Review

Autor:	Geetha Ari, Sandhya Cherukuri, Ambalavanan Namasivayam
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	dna methylation future implications histone modification Medicine
Zdroj:	Journal of Clinical and Diagnostic Research, Vol 10, Iss 11, Pp ZE07-ZE09 (2016)
Druh dokumentu:	article
ISSN:	2249-782X 0973-709X
DOI:	10.7860/JCDR/2016/21025.8864
Popis:	Periodontitis is characterized by infection and inflammation of the tooth supporting structures. Few signs of susceptibility and recurrence after treatment are seen due to the outgrowth of various pathogenic microorganisms. Many studies have been done to understand the genetic basis of periodontal disease. An increased risk for periodontitis has been shown with the variations in genes related to the inflammatory response. Interestingly, some of the genes regulated by epigenetic modifications are modified in response to environmental stimuli. Conditions such as cancer, autoimmune or inflammatory diseases have been dispensed by epigenetic mechanisms. The understanding of these molecular mechanisms and the early detection of susceptibility may guide in future periodontal disease treatment and prevention.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bd43de95a2494177b3294bf35c75ec37 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF