Acylation‐stimulating protein and heart failure progression in arrhythmogenic right ventricular cardiomyopathy

Autor: Jie Ren, Liang Chen, Xiao Chen, Ningning Zhang, Xiaogang Sun, Jiangping Song
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: ESC Heart Failure, Vol 10, Iss 1, Pp 492-501 (2023)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.14218
Popis: Abstract Aims Our previous studies suggested that the complement system was critical in the prognosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). The acylation‐stimulating protein (ASP), generated through the alternate complement pathway, was reported to regulate lipogenesis and triglyceride storage. This study aimed to investigate the role of ASP in predicting adverse cardiac events in an ARVC cohort. Methods and results We enrolled 111 ARVC patients and 106 healthy volunteers, and measured their plasma ASP levels using enzyme‐linked immunosorbent assays. Plasma ASP levels were significantly higher in the ARVC patients than in the healthy controls (2325.22 ± 20.08 vs. 2189.75 ± 15.55, P
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