Anticholesterolemic activity of Moringa oleifera leaves methanolic extract in Triton X-100 induced hypercholesterolemic mice. [Activité anticholestérolémiante de l’extrait méthanolique de la poudre de feuilles de Moringa oleifera sur l’hypercholestérolémie aiguë induite par le Triton X-100 chez des souris.]
| Autor: | Yassamine R. SAIDI, Amel DOUMANDJI |
|---|---|
| Jazyk: | English<br />French |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Nutrition & Santé, Vol 12, Iss 01, Pp 31-37 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2253-0983 2353-026X |
| DOI: | 10.30952/ns.12.1.4 |
| Popis: | Introduction. Moringa oleifera L. is a medicinal plant reported to have thera- peutic potency. Objective. The aim of this work was to study the effect of M. oleifera extract, at a dose of 800 mg/kg, on induced hypercholesterolemia in mice. Material and methods. Male mice (n=30) were used and randomly divided into five equal groups (n=5). Triton X-100 (100mg/kg body weight, i.p.) was administered to induce hypercholesterolemia. Then, oral treatment of Atorvastatin or methanolic extract of M. oleifera leaves (MEMOL) was given daily to treated groups for 7 days. Lipid profile was determined at the end of the treatment. Results. Results showed that mice group treated with MEMOL showed reduced total cholesterol (TC) (136.5 mg/dL), and low density lipoproteins cholesterol (LDL-C) (60.65 mg/dL) levels, when compared to hypercholesterolemic group (242.13 and 168.9 mg/dL for TC and LDL-C, respectively). High density lipoproteins cholesterol (HDL-C) value of treated mice by MEMOL and atorvastatine was comparable and higher than that of other groups. Significant increase in HDL-C level was observed in mice treated with MEMOL. Atherogenic index was signi-fycantly lower (P |
| Databáze: | Directory of Open Access Journals |
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