In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses

Autor: Yuxin Guo, Shao-Zhe Wang, Xinping Zhang, Hao-Ran Jia, Ya-Xuan Zhu, Xiaodong Zhang, Ge Gao, Yao-Wen Jiang, Chengcheng Li, Xiaokai Chen, Shun-Yu Wu, Yi Liu, Fu-Gen Wu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33831-7
Popis: Autologous tumor cell vaccines can elicit anti-tumor immune responses. Here, the authors report the design of dendritic polymer-based nanoparticles loaded with doxorubicin and the tyrosine kinase inhibitor apatinib that can induce immunogenic cell death and the in situ production of immuno-stimulatory micrometer-sized vesicles, promoting anti-tumor immune responses in preclinical models.
Databáze: Directory of Open Access Journals
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