| Autor: |
Ivan Lechner, Martin Reindl, Fritz Oberhollenzer, Christina Tiller, Magdalena Holzknecht, Priscilla Fink, Thomas Kremser, Paolo Bonatti, Felix Troger, Benjamin Henninger, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian J. Reinstadler |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Cardiovascular Magnetic Resonance, Vol 26, Iss 1, Pp 100996- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1097-6647 |
| DOI: |
10.1016/j.jocmr.2024.100996 |
| Popis: |
Background: Dysglycaemia increases the risk of myocardial infarction and subsequent recurrent cardiovascular events. However, the role of dysglycaemia in ischemia/reperfusion injury with development of irreversible myocardial tissue alterations remains poorly understood.In this study we aimed to investigate the association of ongoing dysglycaemia with persistence of infarct core iron and their longitudinal changes over time in patients undergoing primary percutaneous coronary intervention (PCI) for acute ST-segment elevation myocardial infarction (STEMI). Methods: We analyzed 348 STEMI patients treated with primary PCI between 2016 and 2021 that were included in the prospective MARINA-STEMI study (NCT04113356). Peripheral venous blood samples for glucose and glycated hemoglobin (HbA1c) measurements were drawn on admission and 4 months after STEMI. Cardiac magnetic resonance (CMR) imaging including T2 * mapping for infarct core iron assessment was performed at both time points. Associations of dysglycaemia with persistent infarct core iron and iron resolution at 4 months were calculated using multivariable regression analysis. Results: Intramyocardial hemorrhage was observed in 147 (42%) patients at baseline. Of these, 89 (61%) had persistent infarct core iron 4 months after infarction with increasing rates across HbA1c levels ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
