Estrogen-related receptor α (ERRα) functions in the hypoxic injury of microglial cells

Autor: Deng Chao-Yang, Zhu Ting-Ting, Lian Shuai, Wang Jian-Fa, Wu Rui, Zheng Jia-San
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Veterinary Research, Vol 66, Iss 1, Pp 131-140 (2022)
Druh dokumentu: article
ISSN: 2450-8608
DOI: 10.2478/jvetres-2022-0009
Popis: Hypoxia is a common pathological condition after spinal cord injury. Oestrogen-related receptor alpha (ERRα), as a key regulator of energy metabolism and mitochondrial functions, plays an important role in maintaining cell homeostasis. However, its role in hypoxic spinal microglia has not been fully elaborated. This study investigated the receptor’s activity when these cells are hypoxic and used as an in vitro model.
Databáze: Directory of Open Access Journals