A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers

Autor: Gourish Mondal, Meredith Stevers, Benjamin Goode, Alan Ashworth, David A. Solomon
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-09659-z
Popis: Cohesin complex mediates cohesion of sister chromatids and DNA loop formation. Here the authors show another role of cohesin in replication fork progression, suggesting a potential therapeutic strategy for cohesin-mutant cancers.
Databáze: Directory of Open Access Journals